Depakote, also known by its generic name divalproex sodium, is a medication primarily indicated for the treatment of epilepsy, bipolar disorder, and migraines. It belongs to the class of drugs called anticonvulsants and is available in tablet form for oral administration. Depakote works by increasing the levels of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the brain, which helps to calm nerve activity and prevent seizures. Used as a mood stabilizer, it can help manage manic episodes associated with bipolar disorder. Additionally, Depakote can reduce the frequency and severity of migraines. It is important to consult with a healthcare professional for the appropriate usage, potential side effects, and required dosages of Depakote.

Price of Depakote

Depakote pricing spectrum extends from £0.59 to £0.98 for each pills. The key influencers are pack magnitude and the grade of active substances (30 or 360 mg).

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Depakote, also known by its generic name divalproex sodium, is a prescription medication that belongs to the class of drugs known as anticonvulsants. It is primarily used to control seizures in individuals with epilepsy, as well as to treat manic episodes associated with bipolar disorder. Depakote is available in different forms, including oral tablets, delayed-release tablets, and sprinkle capsules. This medication works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain, a neurotransmitter that helps to regulate brain activity. Depakote is typically prescribed and overseen by healthcare professionals, and its dosage and usage should be strictly followed as directed.


Before taking Depakote, it is important to be aware of certain contraindications and factors that may affect its usage. Depakote should not be taken by individuals who have a known hypersensitivity or allergy to the medication or any of its ingredients. Additionally, individuals with liver disease or a history of liver problems should exercise caution when taking Depakote, as it may further exacerbate these conditions. This medication is also not recommended for those with urea cycle disorders or a genetic mitochondrial disorder known as Alpers-Huttenlocher syndrome. Women who are pregnant or planning to become pregnant should consult with their healthcare provider about the potential risks and benefits of taking Depakote due to the possibility of birth defects.

What to Expect When Taking Depakote

As with any medication, Depakote can cause certain side effects. Common side effects of Depakote may include drowsiness, dizziness, tremors, weakness, nausea, vomiting, and changes in appetite or weight. Some individuals may also experience hair loss, menstrual changes, or a decrease in cognitive function. It is important to note that not everyone will experience these side effects, and they may vary in severity. If any side effects become bothersome or persistent, it is important to inform your healthcare provider. Serious side effects such as liver problems, pancreatitis, or a severe allergic reaction are rare, but immediate medical attention should be sought if any of these occur.

Usage Instructions

Depakote should be taken exactly as prescribed by your healthcare provider. It is typically taken orally with food to minimize stomach upset. The dosage will depend on the individual’s condition and their specific treatment plan. It is important to follow the prescribed dosage and to not increase or decrease it without consulting your healthcare provider. If a dose is missed, it is advised to take it as soon as possible. However, if it is closer to the time of the next dose, it is recommended to skip the missed dose and resume the regular dosing schedule. Taking more than the prescribed dose of Depakote can lead to an overdose, which may result in symptoms such as extreme drowsiness, confusion, shallow breathing, or loss of consciousness. In case of an overdose, immediate medical assistance should be sought.

Depakote and Concomitant Drugs

Depakote can interact with certain medications, including those used to treat seizures, antidepressants, antipsychotics, and blood thinners. These interactions can affect the levels of Depakote or the other medications in the body, potentially leading to an increased risk of side effects or a decrease in effectiveness. It is essential to inform your healthcare provider about all medications, including prescription and over-the-counter drugs, as well as any supplements or herbal remedies you are taking. They can determine if any adjustments need to be made or if alternative treatment options should be considered.

Depakote: Inquiry and Response

  • Q: Can I drink alcohol while taking Depakote?

    A: It is generally advised to avoid or limit alcohol consumption while taking Depakote, as it can increase the risk of side effects such as drowsiness and liver damage.

  • Q: Can Depakote be used during pregnancy?

    A: The use of Depakote during pregnancy should be discussed with a healthcare provider, as it may increase the risk of birth defects. In some cases, alternative medications may be recommended.

  • Q: How long does it take for Depakote to start working?

    A: The effects of Depakote can vary from individual to individual. It may take a few weeks or even longer to see the full benefits of the medication. It is important to continue taking it as prescribed and follow up with your healthcare provider.

  • Q: Can Depakote cause weight gain?

    A: Weight gain is a possible side effect of Depakote. However, not everyone will experience this side effect, and it may vary in severity. Maintaining a healthy lifestyle, including a balanced diet and regular exercise, can help manage weight concerns.

  • Q: Can Depakote be abruptly discontinued?

    A: Depakote should not be abruptly discontinued without consulting with a healthcare provider. Sudden discontinuation can lead to withdrawal seizures or worsening of the condition being treated. A gradual tapering schedule may be recommended to safely discontinue the medication.


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