Meldonium

Meldonium, also known as Mildronate, is a pharmaceutical drug that belongs to the class of medications called cardioprotective agents. It is primarily used for the treatment of various cardiovascular disorders, including angina and heart failure. Meldonium is available in oral capsule and injectable forms and is typically prescribed in a dosage strength of 250 mg.

This medication was initially developed in the 1970s by the Latvian Institute of Organic Synthesis as a potential treatment for ischemia, a condition characterized by an inadequate blood supply to the organs. Meldonium exerts its therapeutic effects by enhancing oxygen flow to the tissues and improving cellular energy metabolism.

Restrictions

There are several contraindications to the use of Meldonium that should be considered before starting this treatment. Individuals with hypersensitivity or allergic reactions to the active ingredient of Meldonium, as well as those with severe liver or kidney dysfunction, should avoid taking this drug.

In addition, Meldonium should not be administered to pregnant or breastfeeding women, as there is limited information regarding its safety in these populations. It is important to consult a healthcare professional to assess the risk-benefit ratio before initiating treatment with Meldonium.

Side Effects and Solutions

While Meldonium is generally well-tolerated, it may cause certain side effects in some individuals. Common side effects include headache, nausea, stomach pain, dizziness, and mild allergic reactions like rash or itching. If any of these side effects persist or worsen, it is advisable to seek medical attention.

In rare cases, more serious adverse effects may occur, such as severe allergic reactions, decreased blood pressure, or rhythm disturbances of the heart. If any of these severe side effects manifest, immediate medical intervention is necessary.

To manage the side effects, symptomatic treatment such as antiemetics for nausea or analgesics for headache may be suggested by a healthcare professional.

Administration

Meldonium should be taken as directed by a healthcare professional. The usual recommended dose for adults is 500 mg to 1 g per day, divided into two administrations. The duration of treatment can vary depending on the specific medical condition being treated and the individual’s response to therapy.

If a dose of Meldonium is missed, it should be taken as soon as remembered, unless it is almost time for the next scheduled dose. In such cases, the missed dose should be skipped, and the regular dosing schedule should be resumed. It is important not to take a double dose to make up for a missed one.

An overdose of Meldonium can lead to an intensification of common side effects and may cause severe manifestations like hypotension, tachycardia, or arrhythmias. In case of overdose, immediate medical assistance should be sought.

Special caution should be exercised when administering Meldonium to patients with impaired liver or kidney function, as dose adjustments may be required.

Meldonium Compatibility

Meldonium may interact with certain medications, affecting their effectiveness or increasing the risk of side effects. Concurrent use of Meldonium with nitrate-based drugs (e.g., nitroglycerin) is contraindicated, as it may lead to a potentially dangerous drop in blood pressure.

It is important to inform the healthcare professional about all medications, including over-the-counter drugs, supplements, and herbal products, being used prior to starting Meldonium, to ensure their compatibility and avoid potential drug interactions.

The Answers You Need

• Can Meldonium be used by athletes?

  Since January 1, 2016, Meldonium has been included in the list of prohibited substances by the World Anti-Doping Agency (WADA). As a result, athletes are no longer allowed to use Meldonium during competitions.

• How long does it take for Meldonium to work?

  The onset of action of Meldonium can vary depending on the individual and the specific medical condition. However, noticeable improvements in symptoms may be observed within a few days to a few weeks of initiating treatment.

• Is Meldonium habit-forming?

  No, Meldonium is not considered habit-forming. It does not possess addictive properties and does not lead to physical or psychological dependence.

• Can Meldonium be used during pregnancy?

  The safety of Meldonium during pregnancy has not been established. Therefore, the use of Meldonium is not recommended during pregnancy, unless the potential benefits outweigh the potential risks for the mother and baby.

• Can Meldonium be used in children?

  The use of Meldonium in children has not been extensively studied, and its safety and efficacy in pediatric populations have not been established. Therefore, it is generally not recommended for use in children.