Biological agents for the treatment of Crohn's disease 1

Biological agents for the treatment of Crohn’s disease

What is Crohn’s disease? Crohn’s disease, an autoimmune gastrointestinal disorder, is one of two types of inflammatory bowel disease characterized by possible inflammation throughout the entire thickness of the bowel wall. It has the potential to affect the entire gastrointestinal tract, ranging from the mouth to the colon. This disease typically exhibits wide variability among …

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FDA Grants Approval to Abrysvo for the Prevention of Respiratory Syncytial Virus in Elderly Individuals 5

FDA Grants Approval to Abrysvo for the Prevention of Respiratory Syncytial Virus in Elderly Individuals

The FDA’s approval of Pfizer Inc’s bivalent respiratory syncytial virus (RSV) prefusion F (RSVpreF) vaccine Abrysvo to prevent lower respiratory tract disease caused by RSV in individuals 60 years of age and older is based on foundational basic science discoveries. These discoveries include findings from the National Institutes of Health (NIH) that detail the crystal …

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Revolutionizing Vaccine Delivery with Lipid Nanoparticles against Viral Lung Infections 9

Revolutionizing Vaccine Delivery with Lipid Nanoparticles against Viral Lung Infections

The Potential of Lipid Nanoparticles in mRNA Vaccine Delivery In recent years, researchers have been actively exploring new treatment modalities for infectious diseases, with a particular focus on the development of nanomedicine. Nanomedicine involves the use of nanoscale materials to diagnose and treat diseases, including the targeted delivery of drugs to specific locations within the …

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Unveiling Innovation: 89 New Medicines Approved in Europe in 2022, But How Many Feature Novel Active Ingredients? 15

Unveiling Innovation: 89 New Medicines Approved in Europe in 2022, But How Many Feature Novel Active Ingredients?

European Medicines Agency’s Report for 2022: Protecting and Strengthening Public Health in the European Union The European Medicines Agency (EMA) (official web-site) published its report for the year 2022. The report provides an overview of the measures taken to protect and strengthen public health in the European Union (EU). The EMA recommended the approval of …

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Patients with Rheumatic Diseases Show Improved Pneumococcal Vaccination Rates 19

Patients with Rheumatic Diseases Show Improved Pneumococcal Vaccination Rates

A recent study published in Vaccines found that almost half of patients with autoimmune inflammatory rheumatic diseases (AIIRD) were vaccinated against pneumococcal infection, while more than two-thirds were vaccinated against influenza. These rates suggest an improvement in recent years, although vaccination rates for these viruses remain low in this patient population, who are at higher …

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Novel Dual Gene-Editing Combined with LASER ART Enhances the Possibility of Eliminating HIV Infection 23

Novel Dual Gene-Editing Combined with LASER ART Enhances the Possibility of Eliminating HIV Infection

Researchers published a study in PNAS which found that a promising breakthrough in the elimination of human immunodeficiency virus type 1 (HIV-1) in humanized and infected mice was achieved by combining two CRISPR gene editing therapies with antiretroviral therapy (ART). This revolutionary treatment approach has the potential to transform the management of HIV-1 in humans. …

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Five Common Causes of Fatigue in Parkinson’s Disease 27

Five Common Causes of Fatigue in Parkinson’s Disease

Fatigue is a common symptom experienced by nearly 50% of individuals with Parkinson’s disease, and can be debilitating and persistent, often unrelieved by rest. While fatigue can be a subjective experience, it is important for clinicians to understand potential underlying causes in order to provide appropriate management. Here, we highlight five common causes of fatigue …

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The effectiveness and safety of Veklury® (Remdesivir) have been reaffirmed in groups of patients who are at high risk 35

The effectiveness and safety of Veklury® (Remdesivir) have been reaffirmed in groups of patients who are at high risk

Gilead Sciences, Inc. (Nasdaq: GILD) has reported positive findings from several studies related to COVID-19, which will be presented at the 33rd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID). One Phase 3 clinical trial showed that Veklury® (remdesivir) was well tolerated by patients with moderate to severe renal impairment. In addition, a retrospective …

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Higher Mortality in Pregnant COVID-19 Patients at Early Pandemic Delivery 39

Higher Mortality in Pregnant COVID-19 Patients at Early Pandemic Delivery

JAMA Network Open published a recent national-level analysis from the USA, which identified COVID-19 infection as a severe risk factor for adverse maternal outcomes, including morbidity and mortality, among pregnant women at delivery during the early part of the COVID-19 pandemic. Nevertheless, mortality rates decreased from 232.9 to 79.1 per 100,000 deliveries over the course …

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