Moduretic, known by its generic name amiloride and hydrochlorothiazide, is a medication that is used to treat conditions such as edema and high blood pressure. Edema refers to the excessive accumulation of fluid in the body’s tissues, leading to swelling and discomfort. This drug works by reducing the amount of water and salt that the body retains, thus helping to alleviate symptoms of edema. Additionally, Moduretic helps to lower blood pressure by preventing the reabsorption of salt and water in the kidneys. By decreasing the volume of fluid circulating in the body, this medication assists in reducing the strain on the heart and blood vessels.

Price of Moduretic

A pack of Moduretic can cost anywhere between £0.57 and £0.79. The exact price depends on pack measurements and active ingredient density (60 or 360 mg).

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Moduretic is a medication that is commonly prescribed to treat high blood pressure (hypertension) and edema (fluid retention) in the body. It is a combination drug that contains two active ingredients: amiloride, a potassium-sparing diuretic, and hydrochlorothiazide, a thiazide diuretic. Diuretics work by increasing urine production, which helps to remove excess water and salt from the body. This medication helps to reduce blood volume and lower blood pressure, leading to improved heart function and decreased fluid retention.

What to Avoid When Taking Moduretic

There are certain situations and conditions in which taking Moduretic may not be recommended. If any of the following apply to you, it is important to inform your healthcare provider:

  • Allergy or hypersensitivity to Moduretic or any of its components.
  • Severe kidney disease or a history of kidney stones.
  • Uncontrolled diabetes or gout.
  • Severe liver disease or cirrhosis.
  • Severe dehydration or electrolyte imbalance.
  • Pregnancy or breastfeeding.

Moduretic Reactions

Like any medication, Moduretic can cause certain side effects in some individuals. Common side effects may include:

  • Dizziness or lightheadedness.
  • Headache.
  • Increased urination.
  • Decreased potassium levels.
  • Nausea or vomiting.

It is important to contact your healthcare provider if you experience any severe or persistent side effects while taking Moduretic, as they may need to adjust your dosage or switch you to a different medication.

Dosage Guide

The dosage of Moduretic will vary depending on your individual condition and response to the medication. It is important to follow your healthcare provider’s instructions carefully. Typically, the starting dose for hypertension is 1 tablet (5 mg amiloride/50 mg hydrochlorothiazide) taken once daily. For edema, the starting dose is often 1-2 tablets taken once daily.

If you miss a dose, take it as soon as you remember. However, if it is close to the time of your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

In the case of an overdose, seek immediate medical attention. Symptoms of an overdose may include dizziness, weakness, fainting, and electrolyte imbalances.

Moduretic and Concomitant Drugs

Moduretic has the potential to interact with other medications, which may affect its effectiveness or increase the risk of side effects. Some drugs that may interact with Moduretic include:

Drug Interaction
Nonsteroidal anti-inflammatory drugs (NSAIDs) May reduce the diuretic and antihypertensive effects of Moduretic.
Lithium May increase the risk of lithium toxicity.
Digoxin May increase the risk of digoxin toxicity.
Corticosteroids May reduce the diuretic and antihypertensive effects of Moduretic.

Your Questions Answered

  • Q: Can I take Moduretic with food?
  • A: It is generally recommended to take Moduretic on an empty stomach, at least one hour before or two hours after meals.
  • Q: Can Moduretic cause erectile dysfunction?
  • A: While it is rare, some individuals may experience sexual side effects such as erectile dysfunction while taking Moduretic. If you experience any changes in sexual function, contact your healthcare provider.
  • Q: Can Moduretic be used in children?
  • A: Moduretic is not typically recommended for use in children, as its safety and effectiveness in pediatric patients have not been well-established.
  • Q: Can I drink alcohol while taking Moduretic?
  • A: It is generally advisable to limit alcohol consumption while taking Moduretic, as it may increase the risk of dehydration and other side effects.
  • Q: How long does it take for Moduretic to start working?
  • A: The onset of action for Moduretic varies from individual to individual. However, it may take several weeks for the full therapeutic effects of the medication to be realized.


Active ingredient


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