Prometrium (progesterone) is a prescription medication that belongs to the class of progestins. It is primarily used for hormone replacement therapy in postmenopausal women and for the treatment of secondary amenorrhea (absence of menstrual periods) due to hormonal imbalance. Prometrium is available in the form of capsules for oral administration.
When administered orally, Prometrium is rapidly absorbed and undergoes hepatic metabolism. It is primarily eliminated by the kidneys. The duration of action of Prometrium is approximately 8 to 12 hours.
Prometrium is not indicated for use in pregnancy and should not be used to prevent miscarriage in women who have a history of recurrent miscarriages.
Prometrium is contraindicated in individuals with a known hypersensitivity to progesterone or any of its components. It should also not be used in patients with the following conditions:
- Known or suspected pregnancy
- Undiagnosed vaginal bleeding
- Active or recent thromboembolic disorders
- Hormone-dependent malignancies
- Liver dysfunction or disease
Possible Side Effects
Prometrium may cause several side effects, although not all individuals will experience them. Common side effects include:
- Mood changes
- Nausea and vomiting
- Abdominal pain
- Breast pain
- Irregular vaginal bleeding
- Fluid retention
Less frequently, Prometrium may cause more serious side effects, such as:
- Blood clots
- Deep vein thrombosis
- Pulmonary embolism
- Heart attack
- Breast cancer
- Gallbladder disease
If any of these serious side effects occur, immediate medical attention should be sought.
Prometrium dosing varies depending on the condition being treated. For hormone replacement therapy in postmenopausal women, the usual dose is 200 mg taken orally once daily at bedtime for 12 to 14 consecutive days of a 28-day cycle. For the treatment of secondary amenorrhea, the recommended dose is 400 mg taken orally once daily for 10 days.
If a dose of Prometrium is missed, it should be taken as soon as possible. However, if it is almost time for the next scheduled dose, the missed dose should be skipped and the regular dosing schedule should be continued. Taking a double dose of Prometrium to make up for a missed dose is not recommended.
In the event of an overdose, symptoms may include nausea, vomiting, breast tenderness, dizziness, drowsiness, and vaginal bleeding. Overdose should be treated symptomatically, and supportive measures may be implemented as necessary.
Mixing with Other Drugs
Prometrium may interact with certain drugs, altering their effects or increasing the risk of side effects. It is important to inform a healthcare professional about all medications, vitamins, and herbal supplements being taken.
Prometrium may interact with drugs such as:
- Anticoagulants (blood thinners)
- HIV protease inhibitors
These are not exhaustive lists, and other drug interactions may occur. Consultation with a healthcare professional is essential to ensure the safe and effective use of Prometrium.
Questions and Answers for Prometrium
Q: Can Prometrium be used during pregnancy?
A: No, Prometrium is contraindicated in pregnancy and should not be used during pregnancy.
Q: How should Prometrium be stored?
A: Prometrium should be stored at room temperature, away from moisture and heat.
Q: Can Prometrium cause weight gain?
A: Weight gain is a possible side effect of Prometrium, although it does not occur in all individuals.
Q: Can Prometrium be used for birth control?
A: No, Prometrium is not indicated for use as a birth control method.
Q: What should I do if I miss a dose of Prometrium?
A: If a dose of Prometrium is missed, it should be taken as soon as possible. However, if it is almost time for the next scheduled dose, the missed dose should be skipped and the regular dosing schedule should be continued. Taking a double dose of Prometrium to make up for a missed dose is not recommended.