Tofranil, also known as imipramine, is a medication primarily utilized for the treatment of depression in adults. Classified as a tricyclic antidepressant, Tofranil may also be prescribed to manage symptoms of enuresis (bedwetting) in children. Due to its ability to elevate mood and alleviate depressive symptoms, Tofranil is a widely recognized drug in the field of psychiatry. It is marketed under the brand name Tofranil and is available in various dosage forms such as tablets and capsules.

Price of Tofranil

The common price range for Tofranil lies between £0.4 – £0.95 per pills. This range is subject to the size of the packaging and the potency of the contained ingredients (30 or 360 mg).

SKU: Tofranil Category:

Tofranil, also known by its generic name Imipramine, is a tricyclic antidepressant that is used to treat symptoms of depression, anxiety, and certain types of chronic pain. It works by restoring the balance of certain natural chemicals in the brain, known as neurotransmitters, which are responsible for regulating mood and emotions. Tofranil comes in the form of tablets and is generally taken orally.


Tofranil should not be taken if you have a known allergy to imipramine or any other tricyclic antidepressant. It is important to inform your healthcare provider if you have any of the following conditions:

  • Heart disease or a recent heart attack
  • History of seizures or epilepsy
  • Glaucoma or increased eye pressure
  • Urinary retention or difficulty urinating
  • Hyperthyroidism (overactive thyroid)
  • Recent use of MAO inhibitors

In addition, Tofranil should be used with caution in individuals with a history of bipolar disorder, liver or kidney problems, or those who are pregnant or breastfeeding. It is important to discuss your medical history and any current medications with your healthcare provider before starting Tofranil.

Adverse Reactions

Like any medication, Tofranil can cause certain side effects. Common side effects may include:

  • Drowsiness or dizziness
  • Dry mouth
  • Constipation
  • Blurred vision
  • Increased sweating

Less common but more serious side effects may include:

  • Rapid or irregular heartbeat
  • Confusion or hallucinations
  • Difficulty breathing
  • Severe stomach pain
  • Unusual bleeding or bruising

If you experience any severe or persistent side effects, it is important to seek medical attention immediately.

Dosing Information

The dosing guidelines for Tofranil will vary depending on the individual and the condition being treated. It is important to follow the instructions provided by your healthcare provider and to take the medication as directed. In general, the initial recommended dose for adults is 75 mg per day, divided into multiple doses. This dosage can be adjusted based on individual response and tolerability, but should not exceed 300 mg per day.

If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

In the event of an overdose, seek immediate medical attention. Symptoms of an overdose may include extreme drowsiness, rapid heartbeat, confusion, seizures, and difficulty breathing.

Tofranil and Other Medications

Tofranil can interact with certain medications and substances, potentially leading to adverse effects or reduced effectiveness of either drug. It is important to inform your healthcare provider about all prescription and over-the-counter medications, as well as any herbal supplements or recreational drugs, you are currently taking.

Some medications that may interact with Tofranil include:

Drug Class Examples
MAO inhibitors Phenelzine, Tranylcypromine
Anticoagulants Warfarin, Heparin
Antidepressants Fluoxetine, Sertraline
Antihistamines Diphenhydramine, Loratadine
Benzodiazepines Alprazolam, Diazepam

These lists are not exhaustive, and there may be other medications that can interact with Tofranil. It is important to consult with your healthcare provider or pharmacist for a complete list of potential interactions.


  • 1. Can Tofranil be used for the treatment of chronic pain?

    Yes, Tofranil can be prescribed to help relieve certain types of chronic pain, such as neuropathic pain or migraines.
  • 2. How long does it take for Tofranil to start working?

    The response to Tofranil varies from individual to individual. However, it may take several weeks for the full effect of the medication to be noticeable. It is important to continue taking Tofranil as directed, even if you do not see immediate improvement.
  • 3. Can Tofranil be used in children and adolescents?

    Tofranil may be prescribed for children and adolescents in certain circumstances, such as the treatment of enuresis (bedwetting). However, the dosing and safety of Tofranil in this age group should be closely monitored by a healthcare professional.
  • 4. Are there any dietary restrictions while taking Tofranil?

    There are no specific dietary restrictions associated with Tofranil. However, it is important to maintain a balanced diet and discuss any significant dietary changes with your healthcare provider.
  • 5. Can Tofranil cause withdrawal symptoms if stopped suddenly?

    Discontinuing Tofranil abruptly may lead to withdrawal symptoms. It is recommended to gradually reduce the dosage under the supervision of a healthcare provider to prevent or minimize any potential withdrawal effects.

25mg, 50mg, 75mg

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